Related Experiment Video
Updated: Aug 9, 2026
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
[Expression of perlecan in laryngeal carcinoma cell and its significance]
Guangli Chen1, Juan Ding, Linghui Luo
1Department of Otolaryngology, Union Hospital, Huazhong University of Science and Technology, Wuhan 430022, China.
Objective:
To study the expression of perlecan in human laryngeal carcinoma cells and its significance.
Method:
The expression of perlecan mRNA in human laryngeal carcinoma cells, Hep-2 cells were investigated by using the techniques of semi-quantify RT-PCR. The expression of perlecan in the Hep-2 cells was investigated by using the techniques of immunohistochemistry.
Result:
It showed that the expression level of perlecan and perlecan mRNA significantly increased in Hep-2 cells as compared with the normal cells, Hacat cells (P < 0.01).
Conclusion:
These data raise the possibility that perlecan many play key roles in the growth,invasion and metastasis of human laryngeal carcinoma cells through either a paracrine or an autocrine mechanism.
