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Updated: Aug 9, 2026
07:25
Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
Published on: September 22, 2020
Amputation level viability in critical limb ischaemia: setting new standards
Advances in Experimental Medicine and Biology
|April 6, 2006
Summary
New portable skin oxygen saturation (SO2) device, the RM200, accurately predicts lower limb amputation viability. This validated instrument ensures reliable assessment for critical limb ischemia patients.
Area of Science:
- Vascular Surgery
- Medical Instrumentation
- Physiology
Background:
- Skin oxygen saturation (SO2) measurements previously predicted lower limb amputation healing viability.
- An obsolete instrument for SO2 measurement necessitates validation of a new portable device.
- Differences between instruments may affect amputation level viability criteria.
Purpose of the Study:
- To compare in vivo skin SO2 measurements between a new portable instrument (RM200) and a previous device.
- To validate amputation level viability criteria using the RM200.
- To assess the suitability of the RM200 as a replacement for amputation viability assessments.
Main Methods:
- Skin SO2 measurements were performed on critically ischemic lower limbs of patients.
- Measurements were also taken on normal volunteers' forearms during tourniquet-induced ischemia.
- In vivo measurements were compared between the RM200 and the previous instrument.
Main Results:
- A strong linear correlation (r2 = 0.91) was observed between the two instruments within the 0-40% SO2 range.
- Differences between the instruments were within 1 standard deviation of the mean.
- High agreement was demonstrated between the RM200 and the previous device.
Conclusions:
- The RM200 demonstrates a high degree of agreement with the previous instrument for skin SO2 measurement.
- The RM200 is a suitable and acceptable replacement for the obsolete MCPD instrument.
- The RM200 can be reliably used for amputation level viability assessments in critical limb ischemia.
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