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Updated: Aug 9, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
Published on: December 11, 2017
Cardiac resynchronization therapy as an 'alternative' approach to a non-operable severe aortic stenosis with left
Francesco Antonini-Canterin1, Ferdinando Baldessin, Marco Brieda
1Cardiologia, ARC, Azienda Ospedaliera S. Maria degli Angeli, Pordenone, Italy. cardiologia@aopn.fvg.it
Severe symptomatic aortic stenosis (AS) can be challenging in patients with comorbidities. Biventricular pacing improved a non-operable AS patient with cardiac dyssynchrony, suggesting a potential new therapy.
Area of Science:
- Cardiology
- Cardiac Electrophysiology
Background:
- Severe symptomatic aortic stenosis (AS) typically requires aortic valve replacement.
- Comorbidities complicate surgical indications for AS patients.
- Non-surgical interventions for AS are emerging but lack established roles.
Observation:
- A patient with severe symptomatic AS and cardiac dyssynchrony was deemed non-operable.
- The patient received a biventricular pacemaker for cardiac resynchronization therapy.
- Significant clinical improvement was observed post-pacemaker implantation.
Findings:
- Biventricular pacing effectively treated cardiac dyssynchrony in a non-operable severe symptomatic AS patient.
- This case suggests a potential therapeutic role for cardiac resynchronization therapy in select AS patients.
Implications:
- Cardiac resynchronization therapy may offer a viable treatment option for AS patients unsuitable for surgery.
- Further research is warranted to establish the efficacy and safety of biventricular pacing in AS management.
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