[Determination of the oligobiopolymerized sialic acids in the blood]

A method for measurement of the blood serum (plasma) oligobiopolymerized sialic acids (OSA) has been developed, making use of the known procedures for measuring these amino sugars. Blood OSA levels of normal subjects and intact rats have made up 59.6 +/- 2.3 and 79.0 +/- 3.4 mg/l, respectively. OSA levels were shown to rise in immobilization stress (by 36 percent), aseptic granulomas (by 28 percent), and active phase of rheumatic fever (by 128 percent). The method is recommended for clinical diagnostic studies as an additional diagnostic test.