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Updated: Jul 17, 2026
12:20
Preparation of Segmented Microtubules to Study Motions Driven by the Disassembling Microtubule Ends
Published on: March 15, 2014
Microtubule capture: a concerted effort
Chitra Kotwaliwale1, Sue Biggins
1Fred Hutchinson Cancer Research Center, Division of Basic Sciences, 1100 Fairview Avenue North, A2-168, Seattle, WA 98109, USA.
Cell
|December 19, 2006
Summary
Kinetochore complexes Ndc80 and INCENP-Survivin are crucial for correct chromosome attachment to spindle microtubules during cell division. These findings highlight new roles for these protein complexes in ensuring accurate cell division.
Area of Science:
- Cell Biology
- Molecular Biology
- Genetics
Background:
- Kinetochores mediate chromosome attachment to mitotic spindle microtubules.
- Accurate chromosome segregation is essential for cell division.
Purpose of the Study:
- To elucidate the roles of kinetochore protein complexes Ndc80 and INCENP-Survivin.
- To understand their contribution to establishing correct chromosome-spindle attachments.
Main Methods:
- Analysis of kinetochore protein complexes.
- Investigation of their function during mitosis.
Main Results:
- Ndc80 complex plays a key role in kinetochore-microtubule attachments.
- INCENP-Survivin complex is also vital for correct chromosome attachment.
- These complexes ensure proper chromosome segregation.
Conclusions:
- The Ndc80 and INCENP-Survivin complexes have essential functions in kinetochore-mediated chromosome attachment.
- Their roles are critical for accurate cell division and preventing aneuploidy.
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