[Effect of amber acid on the kidney function in gentamycin-induced nephropathy in white rats]

The amber acid neutralized by 10 % solution of NaOH in a concentration of 250 mmoL/L was administered subcutaneously simultaneously with intraperitonal injection of gentamycin in a doze of 10 mg/kg(bw) once a day during 7 days to the ten nonlinear white male rats, weight 100-120 g exposed to the water-induced diuresis. In these experiments the positive action of an amber acid as energy substratum on some renal function tests was shown: improvement of reabsorbtion in proximal tubules, proved by proteinuria decrease, subsequent normalization of glomerular filtrations followed by uremia reduction and diminishing of other signs of acute renal failure.