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Related Experiment Videos

Hsp90 and developmental networks.

Suzannah Rutherford1, Jennifer R Knapp, Peter Csermely

  • 1Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Mailstop A2-168, 1100 Fairview Avenue North, Seattle, Washington 98109-1024, USA. srutherf@fhcrc.org

Advances in Experimental Medicine and Biology
|January 9, 2007
PubMed
Summary
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Heat shock protein 90 (Hsp90) acts as a molecular buffer, stabilizing cellular communication and controlling sudden morphological changes in organisms. It plays a key role in regulating developmental networks, influencing evolution by managing phenotypic variation.

Area of Science:

  • Molecular biology
  • Developmental biology
  • Evolutionary biology

Background:

  • Heat shock protein 90 (Hsp90) is the most abundant cytoplasmic chaperone in eukaryotic cells.
  • Hsp90 functions as a molecular buffer, influencing developmental regulatory networks and cellular signaling.
  • It conceals variations that could otherwise lead to abrupt morphological changes.

Purpose of the Study:

  • To provide a framework for understanding Hsp90's control over novel morphology emergence.
  • To explore Hsp90's role in mediating phenotypic variation through signal transduction thresholds.
  • To investigate the impact of nonlinearity on cellular responses and morphological changes.

Main Methods:

  • Discussion of hidden polygenic variation.
  • Introduction of signal transduction thresholds concept.

Related Experiment Videos

  • Analysis of nonlinearity in cellular responses.

    • Main Results:

    • Hsp90 conceals developmental and stochastic variations, preventing abrupt morphological changes.
    • Signal transduction thresholds mediate Hsp90's effect on phenotypic variation.
    • Nonlinearity in cellular responses creates thresholds for sudden morphological shifts.

    Conclusions:

    • Hsp90 is crucial for maintaining cellular communication clarity and strength.
    • Hsp90 influences the sudden appearance of novel morphologies by controlling developmental networks.
    • Hsp90 may play a pivotal role in evolutionary morphological stasis and change.