Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Perfusion imaging.

J A Detre1, J S Leigh, D S Williams

  • 1Metabolic Magnetic Resonance Research Center, University of Pennsylvania School of Medicine, Philadelphia 19104.

Magnetic Resonance in Medicine
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characterization of hippocampal subfields using histology-based annotated postmortem MRI: Lessons for in vivo segmentation II.

bioRxiv : the preprint server for biology·2025
Same author

Intensive Blood Pressure Management Preserves Functional Connectivity in Patients with Hypertension from the Systolic Blood Pressure Intervention Randomized Trial.

AJNR. American journal of neuroradiology·2023
Same author

Downstream effects of polypathology on neurodegeneration of medial temporal lobe subregions.

Acta neuropathologica communications·2021
Same author

Cross-modality and in-vivo validation of 4D flow MRI evaluation of uterine artery blood flow in human pregnancy.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2020
Same author

Manganese-Enhanced MRI in Patients with Multiple Sclerosis.

AJNR. American journal of neuroradiology·2020
Same author

A case of ANCA-associated vasculitis presenting de novo in pregnancy, successfully treated with rituximab.

Obstetric medicine·2020
Same journal

Multi-Contrast Human Brain CEST MRI at 11.7 T: First In Vivo Demonstration.

Magnetic resonance in medicine·2026
Same journal

Suppression of Oscillation and Ghosting in RF-Spoiled Gradient-Echo-Based Dynamic Imaging.

Magnetic resonance in medicine·2026
Same journal

A Simple, Dynamic Geometric Phantom for MRI and CT Reconstruction Pipelines: Beyond Shepp-Logan.

Magnetic resonance in medicine·2026
Same journal

7T 3D-EPI PCASL With High SNR Efficiency and Robustness to Through-Plane B<sub>0</sub> Field Gradients.

Magnetic resonance in medicine·2026
Same journal

A Comparison of Tissue Property Values Estimated Using Conventional Cardiac MRF and MT-Cardiac MRF.

Magnetic resonance in medicine·2026
Same journal

Dependence of the Extra-Cellular Diffusion Coefficient on the Fractions of Neurites and Cell Bodies in Gray Matter.

Magnetic resonance in medicine·2026
See all related articles

This study introduces 1H NMR imaging for mapping brain perfusion in rats. The noninvasive technique measures regional cerebral blood flow, offering potential for human studies.

Area of Science:

  • Neuroimaging
  • Physiology
  • Magnetic Resonance Imaging

Background:

  • Tissue perfusion assessment is crucial for in vivo organ function evaluation.
  • 1H NMR imaging offers high resolution for anatomical and physiological studies.

Purpose of the Study:

  • To develop and validate a novel 1H NMR imaging technique for generating brain perfusion maps in rats.
  • To establish a noninvasive method for measuring regional cerebral blood flow (CBF) using endogenous contrast.

Main Methods:

  • Utilized slice-selective saturation imaging to create an endogenous tracer of proximally saturated spins in arterial blood.
  • Employed 1H NMR imaging at 4.7 T to generate perfusion maps based on spin exchange and T1 relaxation.
  • Incorporated distal saturation as a control for saturation pulse effects.

Related Experiment Videos

Main Results:

  • Successfully generated regional perfusion maps in the rat brain.
  • Determined average cerebral blood flow in normocapnic rats under anesthesia to be 105 +/- 16 cc.100 g-1.min-1.
  • Demonstrated sensitivity of the technique to changes in arterial pCO2.

Conclusions:

  • The developed 1H NMR imaging technique provides noninvasive, high-resolution measurement of regional brain perfusion.
  • This method is a valuable tool for assessing cerebral blood flow and shows promise for translation to human studies.