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In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
Microstructural abnormalities in MEWDS demonstrated by ultrahigh resolution optical coherence tomography
My Hanh T Nguyen1, Andre J Witkin, Elias Reichel
1New England Eye Center, Tufts-New England Medical Center, Tufts University, Boston, Massachusetts 02111, USA.
Retina (Philadelphia, Pa.)
|April 11, 2007
Summary
Ultrahigh resolution optical coherence tomography (UHR-OCT) reveals subtle photoreceptor disruptions in acute multiple evanescent white dot syndrome (MEWDS). This imaging technique aids in diagnosing and monitoring this transient retinal condition.
Area of Science:
- Ophthalmology
- Medical Imaging
Background:
- Acute multiple evanescent white dot syndrome (MEWDS) lacks histopathological studies due to its transient nature.
- Ultrahigh resolution optical coherence tomography (UHR-OCT) provides high-resolution in vivo imaging of retinal microstructure.
Observation:
- UHR-OCT imaging of the maculae was performed on five patients diagnosed with MEWDS.
- Diagnostic criteria included clinical presentation, examination, visual field testing, and angiography.
Findings:
- Disturbances in the photoreceptor inner/outer segment (IS/OS) junction were observed in all affected eyes.
- Thinning of the outer nuclear layer was noted in recurrent MEWDS cases, suggesting potential photoreceptor atrophy.
Implications:
- UHR-OCT demonstrates subtle photoreceptor IS/OS disruptions in MEWDS.
- UHR-OCT can serve as a valuable tool for diagnosing and monitoring MEWDS.
