Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 15, 2026

A Fine Motor Task to Study Joint Kinematics in a Preclinical Model of Neurodegenerative Disease
05:39

A Fine Motor Task to Study Joint Kinematics in a Preclinical Model of Neurodegenerative Disease

Published on: June 13, 2025

Lower extremity motor function and disability in mild cognitive impairment.

P A Boyle1, R S Wilson, A S Buchman

  • 1Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA. Patricia_Boyle@rush.edu

Experimental Aging Research
|May 15, 2007
PubMed
Summary

Mild cognitive impairment (MCI) is linked to poorer gait and balance. This motor dysfunction in MCI contributes to disability and is not explained by vascular factors alone.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Direct observation of muonic molecules in resonance states critical to muon catalyzed fusion.

Science advances·2026
Same author

Harmonization of late-life participation in cognitively stimulating activities across four cohort studies of cognitive aging.

Experimental gerontology·2026
Same author

Nose-to-brain translocation of inhaled ultrafine elongated particles: facts and mysteries.

Frontiers in toxicology·2025
Same author

Most Stringent Bound on Electron Neutrino Mass Obtained with a Scalable Low-Temperature Microcalorimeter Array.

Physical review letters·2025
Same author

Few-Electron Highly Charged Muonic Ar Atoms Verified by Electronic K X Rays.

Physical review letters·2025
Same author

A Highly Linear Calibration Metric for TES X-ray Microcalorimeters.

Journal of low temperature physics·2025

Area of Science:

  • Neurology
  • Gerontology
  • Movement Science

Background:

  • Mild cognitive impairment (MCI) may involve lower extremity motor dysfunction.
  • The specific nature and impact of motor deficits in MCI are not well understood.

Purpose of the Study:

  • To investigate the association between MCI and impairments in gait, balance, and strength.
  • To determine the relationship between lower extremity function and disability in individuals with MCI.

Main Methods:

  • Analysis of gait, balance, and strength in individuals with and without MCI.
  • Inclusion of adjustments for age, sex, education, vascular risk factors, and vascular disease.
  • Utilized data from the Rush Memory and Aging Project.

Main Results:

More Related Videos

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients
07:42

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients

Published on: December 16, 2022

Motor Imagery Brain-Computer Interface in Rehabilitation of Upper Limb Motor Dysfunction After Stroke
09:42

Motor Imagery Brain-Computer Interface in Rehabilitation of Upper Limb Motor Dysfunction After Stroke

Published on: September 1, 2023

Related Experiment Videos

Last Updated: Jul 15, 2026

A Fine Motor Task to Study Joint Kinematics in a Preclinical Model of Neurodegenerative Disease
05:39

A Fine Motor Task to Study Joint Kinematics in a Preclinical Model of Neurodegenerative Disease

Published on: June 13, 2025

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients
07:42

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients

Published on: December 16, 2022

Motor Imagery Brain-Computer Interface in Rehabilitation of Upper Limb Motor Dysfunction After Stroke
09:42

Motor Imagery Brain-Computer Interface in Rehabilitation of Upper Limb Motor Dysfunction After Stroke

Published on: September 1, 2023

  • Individuals with MCI demonstrated significantly impaired gait and balance compared to cognitively unimpaired individuals.
  • The association between MCI and motor dysfunction persisted even after accounting for vascular factors.
  • Among those with MCI, gait and balance impairments were linked to a higher likelihood of disability.

Conclusions:

  • Lower extremity motor dysfunction is prevalent in MCI and contributes to functional disability.
  • The observed motor deficits in MCI are not solely attributable to the vascular factors investigated.