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Published on: June 4, 2012
Infective endocarditis due to penicillin-resistant viridans group streptococci
Bettina Knoll1, Imad M Tleyjeh, James M Steckelberg
1Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. Knoll.Bettina@mayo.edu
Summary
Penicillin-resistant viridans group streptococci endocarditis can be successfully treated with current guidelines. This study reviewed treatment outcomes for 29 patients, showing positive results for both native and prosthetic valve infections.
Area of Science:
- Infectious Diseases
- Cardiology
- Microbiology
Background:
- Increasing global recognition of penicillin-resistant viridans group streptococci.
- Limited data on infective endocarditis caused by these resistant strains.
- Treatment recommendations often rely on expert consensus due to data scarcity.
Purpose of the Study:
- To analyze treatment regimens and outcomes for infective endocarditis caused by penicillin-resistant viridans group streptococci.
- To evaluate the effectiveness of current treatment guidelines in a real-world patient cohort.
Main Methods:
- Retrospective cohort study of 29 patients with infective endocarditis due to penicillin-resistant viridans group streptococci.
- Data collected from January 1967 to April 2006 at the Mayo Clinic.
- Analysis of demographic characteristics, clinical features, treatment regimens, and patient outcomes.
Main Results:
- Nineteen of 19 patients with native valve endocarditis were cured.
- Nine of 10 patients with prosthetic valve endocarditis achieved cure.
- Treatment durations varied, with combination therapies and monotherapy showing success.
Conclusions:
- Current treatment guidelines appear effective for managing infective endocarditis caused by penicillin-resistant viridans group streptococci.
- Successful outcomes observed in both native and prosthetic valve endocarditis cases.
- Prolonged follow-up supports the applicability of existing therapeutic strategies.
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