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Published on: October 4, 2016
Vertically aligned carbon nanofiber architecture as a multifunctional 3-D neural electrical interface.
T D Barbara Nguyen-Vu1, Hua Chen, Alan M Cassell
1NASA Ames Research Center, Moffett Field, CA 94035, USA. bnguyenv@stanford.edu
IEEE Transactions on Bio-Medical Engineering
|June 8, 2007
Summary
Vertically aligned carbon nanofiber (VACNF) arrays create a 3-D matrix for neural cells, enhancing neural network formation. This biomaterial platform offers precise control for developing advanced neural devices.
Area of Science:
- Biomaterials Science
- Neuroscience
- Nanotechnology
Background:
- Developing implantable devices requires biomaterials mimicking the natural tissue microenvironment.
- Neural-electrical interfaces need reliable materials for improved function.
Purpose of the Study:
- To demonstrate vertically aligned carbon nanofiber (VACNF) arrays as a multifunctional 3-D nanoengineered matrix.
- To explore VACNF's potential for neural cell culture and implantable neural devices.
Main Methods:
- Culturing PC12 neuron cells on VACNF substrates.
- Utilizing chemical and biochemical modifications for network formation.
- Employing micropatterned multiplex VACNF arrays for electrical and electrochemical control.
Main Results:
- PC12 cells formed extended neural networks on VACNF substrates.
- The 3-D VACNF architecture allowed fine-tuning of topographical, mechanical, chemical, and electrical cues.
- Localized stimulation with high spatiotemporal resolution was achieved using micropatterned arrays.
Conclusions:
- VACNF arrays serve as a versatile platform for studying material-cell interactions.
- This technology can lead to the development of chronically stable implantable neural devices.
- Potential for highly multiplexed closed-loop systems for neuromodulation and neuroprostheses.
