Related Experiment Video
Updated: Jul 13, 2026
10:41
Conjugative Mating Assays for Sequence-specific Analysis of Transfer Proteins Involved in Bacterial Conjugation
Published on: January 4, 2017
Molecular basis for the unique specificity of TRAF6
Jee Y Chung1, Miao Lu, Qian Yin
1Department of Biochemistry, Weill Medical College of Cornell University, New York, New York 10021, USA.
Advances in Experimental Medicine and Biology
|July 18, 2007
Summary
Tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) is crucial for immune responses and tissue development. Understanding TRAF6
Area of Science:
- Molecular Biology
- Immunology
- Biochemistry
Background:
- TRAF6 is a key adaptor protein in TNF receptor and IL-1/Toll-like receptor signaling.
- It regulates critical physiological processes including immunity and bone metabolism.
Purpose of the Study:
- To review structural and biochemical studies of TRAF6.
- To explore peptidomimetic drug potential based on TRAF6 interactions.
Main Methods:
- Structural analysis of TRAF6.
- Biochemical assays of TRAF6 receptor binding.
- Review of existing literature.
Main Results:
- TRAF6 mediates signals from distinct receptor families.
- Its structure and binding motifs are critical for its function.
- Peptidomimetics offer a potential therapeutic avenue.
Conclusions:
- TRAF6 is a versatile regulator of immunity and development.
- Targeting TRAF6-receptor interactions could yield novel therapeutics.
Related Concept Videos
02:36Transfer RNA Synthesis
One of the unique features of tRNA is the presence of modified bases. In some tRNAs, modified bases account for nearly 20% of the total bases in the molecule. Altogether, these unusual bases protect the tRNA from enzymatic degradation by RNases.
Each of these chemical modifications is carried by a specific enzyme, post-transcription. All of these enzymes have unique base and site-specificity. Methylation, the most common chemical modification, is carried by at least nine different enzymes, with...
Each of these chemical modifications is carried by a specific enzyme, post-transcription. All of these enzymes have unique base and site-specificity. Methylation, the most common chemical modification, is carried by at least nine different enzymes, with...
01:11Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
01:30General Transcription Factors
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
02:16Transcription Factors
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
01:57Protein Complexes with Interchangeable Parts
Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
02:32Exon Recombination
The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes.
Exon shuffling follows “splice frame rules.” Each exon has three reading...
Exon shuffling follows “splice frame rules.” Each exon has three reading...