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Segmental neurovascular syndromes in children
T Krings1, S Geibprasert, C B Luo
1Service de Neuroradiologie Diagnostique et Thérapeutique, Hôpital Bicêtre, 78 rue du Général Leclerc, 94275 Le Kremlin-Bicêtre, Paris, France. tkrings@izkf.rwth-aachen.de
Neuroimaging Clinics of North America
|July 25, 2007
Summary
Segmental vascular syndromes link brain, bone, and face disorders. A shared embryonic origin from neural crest and mesoderm cells may explain these rare, interconnected conditions.
Area of Science:
- Developmental biology
- Neuroscience
- Genetics
Background:
- Segmental vascular syndromes present diverse clinical manifestations.
- These syndromes appear unrelated but may share an underlying developmental origin.
Purpose of the Study:
- To explore the embryological basis of segmental vascular syndromes.
- To investigate the potential link between neural crest/mesoderm development and these conditions.
Main Methods:
- Review of embryological principles of neural crest and mesoderm migration.
- Postulation of somatic mutations in early development.
Main Results:
- Neural crest and cephalic mesoderm migration patterns connect cranial structures.
- Somatic mutations in these cells could lead to arterial or venous metameric syndromes.
Conclusions:
- PHACES, CAMS, Cobb syndrome, and Sturge-Weber syndrome may share a common etiological basis.
- Understanding this linkage can illuminate the pathology of cerebral vascular disorders.
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