Related Experiment Video
Updated: Jul 11, 2026
14:55
Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
Published on: September 17, 2017
Some developments in nuclear magnetic resonance of solids
Science (New York, N.Y.)
|October 6, 1989
Summary
Modern Nuclear Magnetic Resonance (NMR) spectroscopy advances solid-state analysis. New techniques reveal complex molecular structures and dynamics, enhancing understanding across physics, chemistry, biology, geology, and materials science.
Area of Science:
- Solid-state Nuclear Magnetic Resonance (NMR) spectroscopy.
- Analytical chemistry and materials science.
Background:
- Nuclear Magnetic Resonance (NMR) spectroscopy is a key technique for studying solid materials.
- Continuous advancements are expanding its analytical capabilities.
Purpose of the Study:
- To review recent developments in modern NMR spectroscopy for solid-state analysis.
- To highlight the technique's potential across diverse scientific fields.
Main Methods:
- Sample reorientation for motional narrowing.
- Multiple-quantum and overtone spectroscopy.
- Probing porous solids with guest molecules.
- 2D NMR for chemical exchange and spin diffusion.
- Experiments at extreme temperatures.
- NMR imaging of solid materials.
- Low-frequency and zero-field magnetic resonance.
Main Results:
- Modern NMR techniques allow for detailed probing of molecular-level structural and dynamical behavior in solids.
- These advancements enhance the understanding of macroscopic material properties.
Conclusions:
- Developments in NMR spectroscopy significantly expand its utility as an analytical tool.
- NMR provides molecular-level insights crucial for diverse scientific disciplines, including physics, chemistry, biology, geology, and materials science.
Related Concept Videos
01:05Atomic Nuclei: Magnetic Resonance
The number of nuclear spins aligned in the lower energy state is slightly greater than those in the higher energy state. In the presence of an external magnetic field, as the spins precess at the Larmor frequency, the excess population results in a net magnetization oriented along the z axis. When a pulse or a short burst of radio waves at the Larmor frequency is applied along the x axis, the coupling of frequencies causes resonance and flips the nuclear spins of the excess population from the...
01:23Atomic Nuclei: Nuclear Relaxation Processes
In the absence of an external magnetic field, nuclear spin states are degenerate and randomly oriented. When a magnetic field is applied, the spins begin to precess and orient themselves along (lower energy) or against (higher energy) the direction of the field. At equilibrium, a slight excess population of spins exists in the lower energy state. Because the direction of the magnetic field is fixed as the z-axis, the precessing magnetic moments are randomly oriented around the z-axis. This...
01:07Nuclear Magnetic Resonance (NMR): Overview
Nuclear magnetic resonance (NMR) is a phenomenon exhibited by certain nuclei that can absorb characteristic radio frequency radiation under certain conditions. NMR has been extensively applied in molecular spectroscopy and medical diagnostic imaging. In both these applications, the molecule or subject under study is placed in a magnetic field and irradiated with radio frequency energy.
NMR spectroscopy generates a spectrum where the characteristic absorption frequencies of the sample are...
NMR spectroscopy generates a spectrum where the characteristic absorption frequencies of the sample are...
01:12Double Resonance Techniques: Overview
Double resonance techniques in Nuclear Magnetic Resonance (NMR) spectroscopy involve the simultaneous application of two different frequencies or radiofrequency pulses to manipulate and observe two distinct nuclear spins. One important application of double resonance is spin decoupling, which selectively suppresses coupling with one type of nucleus while observing the NMR signal from another nucleus, simplifying the spectrum and enhancing resolution.
Spin decoupling is usually achieved by...
Spin decoupling is usually achieved by...
01:25Applications Of NMR In Biology
Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.
The...
The...
01:14NMR Spectrometers: Resolution and Error Correction
When magnetic nuclei in a sample achieve resonance and undergo relaxation, the signal detected in NMR is an approximately exponential free induction decay. Fourier transform of an exponential decay yields a Lorentzian peak in the frequency domain. Lorentzian peaks in an NMR spectrum are defined by their amplitude, full width at half maximum, and position, where the peak width is governed by the spin-spin relaxation time alone. In real experiments, however, the applied magnetic field is rendered...