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Elevated body temperature exaggerates laryngeal chemoreflex apnea in decerebrate piglets
Luxi Xia1, Tracey Damon, J C Leiter
1Dartmouth Medical School, Department of Physiology, USA.
Advances in Experimental Medicine and Biology
|December 19, 2007
Abstract:
We investigated the interaction between body temperature and the duration of the laryngeal chemoreflex (LCR) in decerebrate piglets. Elevating body temperature by approximately 2 degrees C prolongs the duration of the LCR and the length of apnea associated with the reflex. This thermal prolongation seems to arise within the nucleus of the solitary tract in the brainstem, and we believe the thermal effect is mediated by enhanced GABAergic neurotransmission.
