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Updated: Jul 9, 2026

Electrophysiology on Isolated Brainstem-spinal Cord Preparations from Newborn Rodents Allows Neural Respiratory Network Output Recording
Published on: November 19, 2015
Computational model of TASK channels and PKC-pathway dependent serotonergic modulatory effects in respiratory-related
Tzu-Hsin B Tsao1, Robert J Butera
1Laboratory for Neuroengineering, Georgia Institute of Technology, Atlanta, GA, USA.
Abstract:
Hypoglossal motoneurons (HMs) receive serotonergic innervations from medullary raphe neurons and produce rhythmic discharge patterns closely associated with respiratory rhythm generated in the pre-Bötzinger complex (pBC). HM activity is subject to modulation by numerous factors including serotonin (5-HT), TRH, norepinephrine (NE), substance P (SP), pH, multiple protein kinases and phosphatases. In this present work, we introduce a computational HM model that facilitates the investigation of how neuromodulatory factors such as 5-HT and pH, can affect HM activities.
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