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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
Inherited thrombophilia and the eye
Cheryl Czerlanis1, Walter M Jay, Sucha Nand
1Department of Medicine, Loyola University Medical Center, Maywood, IL 60153, USA.
Seminars in Ophthalmology
|March 6, 2008
Summary
Inherited thrombophilia, including Factor V Leiden and hyperhomocysteinemia, may support eye thrombosis risk. More research is needed to confirm the link between these inherited clotting disorders and ocular thrombotic events.
Area of Science:
- Ophthalmology
- Hematology
- Genetics
Background:
- Inherited thrombophilic disorders are known risk factors for systemic thromboembolism.
- These include deficiencies in anticoagulant proteins (protein C, S, antithrombin III) and genetic mutations (Factor V, prothrombin).
- Hyperhomocysteinemia is linked to both venous and arterial thrombosis, while others primarily cause venous thromboembolism.
Purpose of the Study:
- To review the association between inherited thrombophilia and the development of thrombosis in the eye.
- To explore the potential role of genetic hypercoagulable states in ocular vascular events.
Main Methods:
- Literature review of case-control studies and case reports.
- Analysis of existing data on inherited thrombophilia and eye thrombosis.
Main Results:
- Preliminary data suggest a relationship between ocular thrombotic disorders and inherited hypercoagulable states.
- Factor V Leiden and hyperhomocysteinemia showed some association with thrombosis risk, but this often disappeared in multivariate analysis.
- Inherited thrombophilia may play a supportive role alongside established risk factors like hypertension and diabetes.
Conclusions:
- The role of inherited thrombophilia in the development of thrombotic disorders of the eye requires further investigation.
- Larger, well-designed studies are necessary to definitively establish this association.
- Current evidence suggests a potential, but not fully confirmed, link between inherited clotting tendencies and eye thrombosis.
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