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Mitomycin C in photorefractive keratectomy: effect on epithelialization and predictability.
1Ophthalmic Surgery Unit, Casa di Cura Rugani, Siena, Italy. leccisotti@libero.it
Cornea
|March 26, 2008
Summary
Topical mitomycin C (MMC) after myopic photorefractive keratectomy (PRK) did not delay healing. However, MMC did result in a slight overcorrection and reduced haze formation in the treated eyes.
Area of Science:
- Ophthalmology
- Refractive Surgery
- Corneal Surgery
Background:
- Myopic photorefractive keratectomy (PRK) is a common refractive surgery procedure.
- Haze formation and refractive predictability are key concerns following PRK.
Purpose of the Study:
- To evaluate the impact of topical mitomycin C (MMC) on epithelialization and refractive predictability after myopic PRK.
- To assess the safety and efficacy of MMC in reducing postoperative haze.
Main Methods:
- A prospective, randomized, double-masked, paired-eye study was conducted.
- Fifty-two patients with moderate to high myopia underwent bilateral PRK, with one eye receiving MMC and the other a control (balanced salt solution).
- Epithelialization time, refractive outcomes, and haze formation were assessed over 12 months.
Main Results:
- Topical MMC did not significantly alter the mean epithelialization time compared to the control group.
- Eyes treated with MMC showed a statistically significant reduction in corneal haze at 12 months.
- A mean overcorrection of 0.47 D was observed in the MMC-treated eyes.
Conclusions:
- Topical mitomycin C (MMC) is safe and does not impede epithelial healing after myopic PRK.
- MMC effectively reduces postoperative haze formation.
- A slight myopic overcorrection may occur with MMC use, requiring careful consideration in refractive planning.
