Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stem cells remember their grade.

Cristina Lo Celso1, David T Scadden

  • 1Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Stem Cell Institute, Boston, MA 02114, USA.

Cell Stem Cell
|March 29, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single-Cell Translation and Apoptosis Profiling to Define Human CD34 <sup>+</sup> Cell Response to Specific Factors.

bioRxiv : the preprint server for biology·2026
Same author

Intermittent parathyroid hormone employs autonomous and non-autonomous mechanisms to drive osteogenesis from Ebf3-expressing skeletal progenitor cells.

bioRxiv : the preprint server for biology·2026
Same author

Shifting IRES versus Cap-initiated translation during homeostatic stem cell differentiation and stress.

Science advances·2026
Same author

Optimizing scheduling in dual-pulse nucleoside labeling experiments for cell-cycle analysis.

Biophysical journal·2026
Same author

Iron overload damages mitochondria and induces metabolic rewiring of hematopoietic stem cells toward glycolysis.

Blood·2026
Same author

Protein <i>S</i>-acylation dynamics provide metabolic plasticity to acute myeloid leukemia cells.

bioRxiv : the preprint server for biology·2026
Same journal

Psychological stress drives aging-like hematopoietic stem cell dysfunction through a brain-gut-bone marrow axis.

Cell stem cell·2026
Same journal

Human stem cell-based embryo model governance: Insights from Japan.

Cell stem cell·2026
Same journal

From reconstruction to intervention: Engineered organoids as living therapeutic depots.

Cell stem cell·2026
Same journal

Long-term lessons from MATCH01 macrophage therapy in cirrhosis.

Cell stem cell·2026
Same journal

Beyond apoptosis: LSC state dictates metabolic and anti-apoptotic vulnerabilities.

Cell stem cell·2026
Same journal

Outside the niche: Gut microbiota relay psychological stress to hematopoietic stem cell dysfunction.

Cell stem cell·2026
See all related articles

Hematopoietic stem cells exhibit a graded state, not just a binary one. This cellular gradation is maintained in their daughter cells, offering new insights into stem cell biology.

Area of Science:

  • Hematology
  • Stem Cell Biology
  • Cellular Differentiation

Background:

  • Current understanding of stem cell state relies on performance assays, which are indirect measures of a complex cellular condition.
  • The precise nature and inheritance of the stem cell state remain incompletely understood.

Discussion:

  • Dykstra et al. (2007) investigated the concept of stem cell gradation within hematopoietic stem cells.
  • The study explored the degree to which this cellular gradation is preserved in the progeny of these stem cells.

Key Insights:

  • Stem cells exist on a spectrum or gradation, rather than a simple on/off state.
  • This observed gradation in hematopoietic stem cells is demonstrably passed down to their daughter cells.

Outlook:

Related Experiment Videos

  • These findings challenge simplistic views of stem cell identity and function.
  • Understanding stem cell gradation may refine therapeutic applications and disease modeling in hematopoiesis.