[The stress generated potential in the femur during different modes of mechanical loading in rats]

It was studied the stress generated potential (SGP) of moist femur bones of 24 Vistar rats-males in normo- and hypokinesia conditions. The mechanical loading on bone was evened 30-50 and 100% from animal body mass. The mechanical pressure was carried out in axial direction. The rats stay in hard hypokinesia for 28 days. In all experiments Ag-AgCl with a salt bridge from 0,9% NaCl in 2% agar were utilized (Cochran G.V. et al., 1989). It was set that amplitude of electric potential which arises up in bones at the mechanical loading depends on the level of this loading. However there is a certain optimum of the mechanical loading which provides the maximal increase of SGP. This optimum is in the range of physiology level of loadings. At development of hypokinetic osteopenia SGP diminished most substantially in the range ofphysiology level loadings also. It may be one of reasons of low efficiency of the physical loadings at development age-old osteopenia and slow renewal of bone tissue after hypokinesia.