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Updated: Jul 3, 2026

Tracking Mouse Bone Marrow Monocytes In Vivo
12:08

Tracking Mouse Bone Marrow Monocytes In Vivo

Published on: February 27, 2015

Noninvasive cell tracking.

Fabian Kiessling1

  • 1Abteilung Medizinische Physik in der Radiologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg. f.kiessling@dkfz.de

Handbook of Experimental Pharmacology
|July 16, 2008
PubMed
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Noninvasive cell tracking is crucial for cell-based therapies. Methods like leukocyte scintigraphy, MRI with iron oxide particles, and optical imaging with fluorescent proteins enable in vivo monitoring for research and clinical applications.

Area of Science:

  • Biomedical Engineering
  • Cell Biology
  • Medical Imaging

Background:

  • Cell-based therapies show promise for treating diseases like cancer and neurodegenerative disorders.
  • Noninvasive cell tracking is essential for understanding cell migration and improving clinical translation of these therapies.

Purpose of the Study:

  • To review and discuss various in vivo cell labeling and tracking methods.
  • To highlight the strengths and limitations of different noninvasive cell tracking techniques.

Main Methods:

  • Leukocyte scintigraphy for semi-quantitative assessment and inflammation localization.
  • Magnetic Resonance Imaging (MRI) using ultrasmall superparamagnetic iron oxide particles (USPIO) for single-cell visualization.
  • Optical imaging techniques employing fluorescent dyes, quantum dots, or fluorescent proteins (e.g., GFP, RFP).

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Related Experiment Videos

Last Updated: Jul 3, 2026

Tracking Mouse Bone Marrow Monocytes In Vivo
12:08

Tracking Mouse Bone Marrow Monocytes In Vivo

Published on: February 27, 2015

In vivo 19F MRI for Cell Tracking
10:05

In vivo 19F MRI for Cell Tracking

Published on: November 25, 2013

Monitoring Dendritic Cell Migration using 19F / 1H Magnetic Resonance Imaging
08:12

Monitoring Dendritic Cell Migration using 19F / 1H Magnetic Resonance Imaging

Published on: March 20, 2013

Main Results:

  • Leukocyte scintigraphy is the only clinically established method for cell tracking.
  • USPIO-labeled cells can be visualized with MRI, with clinical translation demonstrated for dendritic cells in lymph nodes.
  • Fluorescent protein labeling allows tracking of proliferating cells, beneficial for tumor cell imaging.

Conclusions:

  • Multiple promising noninvasive cell tracking options exist with varying advantages and disadvantages.
  • Method selection depends on the specific requirements of cell-tracking experiments.
  • Advancements in cell tracking are vital for the progress of cell-based therapies.