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Related Experiment Video

Updated: Jul 3, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Multiple endocrine neoplasia syndromes.

Glenda G Callender¹, Thereasa A Rich, Nancy D Perrier

¹Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, 1400 Holcombe Boulevard, Unit 444, Houston, TX, USA.

The Surgical Clinics of North America

|August 2, 2008

Summary

Multiple endocrine neoplasia (MEN) syndromes are rare genetic disorders leading to tumors in various endocrine glands. This review covers their clinical features, diagnosis, and management for affected individuals.

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Published on: August 25, 2023

Area of Science:

Endocrinology
Genetics
Oncology

Background:

Multiple endocrine neoplasia (MEN) syndromes are inherited conditions predisposing individuals to tumors in endocrine and nonendocrine organs.
Classic types include MEN type 1 and MEN type 2, but other hereditary syndromes share features.

Purpose of the Study:

To review the clinical manifestations, diagnostic approaches, and surgical management strategies for various MEN syndromes.
To discuss genetic risk assessment for individuals with endocrine neoplasms.

Main Methods:

Literature review of clinical features, diagnosis, and management of MEN syndromes.
Discussion of genetic basis and risk assessment for hereditary endocrine neoplasia.

Main Results:

MEN syndromes involve tumors of the pituitary, thyroid, parathyroids, adrenals, pancreas, and other organs.
Includes classic MEN types and related hereditary conditions like VHL and Cowden syndrome.

Conclusions:

Comprehensive understanding of MEN syndromes is crucial for accurate diagnosis and effective management.
Genetic risk assessment plays a vital role in identifying and monitoring affected families.