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Updated: Jul 1, 2026

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis
Published on: September 10, 2014
Recognizing and controlling biomolecules with "Smart" hybridization-based switches
Oliver Seitz1, Tom N Grossmann, Stefanie Thurley
1Institute of Chemistry, Humboldt University Berlin, Brook-Taylor-Str. 2, D-12489 Berlin, Germany. oliver.seitz@chemie.hu-berlin.de
Abstract:
The rules that govern the formation of DNA duplex structures are well known. On one hand, this process is used in the design of probe molecules that report the presence of target nucleic acids by responding to changes of structure and reactivity. On the other hand, molecules may be developed that transduce changes of nucleic acid structure to changes of peptide structure, and vice versa. Applications in the fields of bioanalytical chemistry and synthetic biology are discussed.
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