Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Setting Time of Cement

Setting Time of Cement

The setting time of cement refers to the process of cement paste transitioning from a plastic state to a solid state. This process is crucial in construction as it dictates the timeframe for concrete placement, compaction, and finishing. The onset of this solidification is termed the initial set, indicating when the paste becomes unworkable. The final set is when the paste has solidified completely, and further handling or manipulation can no longer affect its shape. The cement strength is...

Development of the Heart

Development of the Heart

The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart tube by...

Three Developmental Domains

Three Developmental Domains

Human development is typically examined across three main domains: physical, cognitive, and socio-emotional. These domains represent the significant areas of change and continuity throughout the lifespan, from infancy to late adulthood.
Physical Development
Physical processes, also known as maturation, encompass the biological changes that occur across an individual's life. These changes begin with genetic inheritance and continue through various stages, including growth in height and weight,...

Sustainable Development

Sustainable Development

As the human population continues to grow and use resources, we must be mindful of our planet’s natural limits. Sustainable development provides a pathway to maintain and improve human life now while also ensuring that future generations will have the resources that they need. The long-term success of sustainability efforts rests on understanding the interplay between human actions and ecological systems.

Introduction to Developmental Psychology

Introduction to Developmental Psychology

Developmental psychology explores the changes and continuities in human abilities throughout life, encompassing physical, cognitive, linguistic, and social dimensions. Human development is not restricted to growth, but includes aspects of decline, particularly in physical abilities as individuals age. Developmental psychologists seek to understand how people change as they age and how their mental and social skills evolve.Developmental MilestonesA key concept in developmental psychology is...

Mixing Time

Mixing Time

The concept of mixing time is significant in producing a uniform concrete mix with the required strength. The mixing period starts once all components are in the mixer. Initially, the mixer is charged with 10% of the water, followed by the consistent addition of solids and then 80% of the water. The remaining water is added later, within the first quarter of the mixing period. The minimum mixing time varies according to the mixer's capacity; for example, mixers with up to 1 cubic yard capacity...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

When ART meets nature: Heterotopic pregnancy following single embryo transfer.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics·2026

Same author

A toolkit for mapping cell identities in relation to neighbors reveals conserved patterning of neuromesodermal progenitor populations.

PLoS biology·2025

Same author

NOTCH1 S2513 is critical for the regulation of NICD levels impacting the segmentation clock in hiPSC-derived PSM cells and somitoids.

Genes & development·2025

Same author

Tooth Wear Prevalence and Associated Risk Factors Among a Small Portuguese Community: A Retrospective Study.

Journal of clinical medicine·2025

Same author

Establishment of an induced pluripotent cell line (ABCRIi001-A) from an elderly female for ageing research.

Stem cell research·2024

Same author

DYNC2H1 splicing variants causing severe prenatal short-rib polydactyly syndrome and postnatal orofaciodigital syndrome.

Annals of human genetics·2024

Same journal

Mammalian Respiratory Chain Complex Assemblies and Their Links to Mitochondria Stress-Induced Human Diseases.

Advances in experimental medicine and biology·2026

Same journal

Enzyme Assemblies in Nucleotide Metabolism: Structure, Regulation, and Disease Implications.

Advances in experimental medicine and biology·2026

Same journal

The Pyruvate Dehydrogenase Complex: A 90-Year-Old Enigma Shaping the Future of Structural Enzymology.

Advances in experimental medicine and biology·2026

Same journal

Regulation of the Anti-termination RNA Transcription Complex by Lon-Mediated Lambda N Degradation.

Advances in experimental medicine and biology·2026

Same journal

PCNA Macromolecular Complexes: PCNA Serves as a Molecular Hub Regulating Multiple Cellular Processes Inside and Outside of the Nucleus.

Advances in experimental medicine and biology·2026

Same journal

Dynamic Assemblies in Genome Maintenance.

Advances in experimental medicine and biology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 1, 2026

Mouse Embryonic Development in a Serum-free Whole Embryo Culture System

Mouse Embryonic Development in a Serum-free Whole Embryo Culture System

Published on: March 1, 2014

Development on time.

Isabel Palmeirim¹, Sofia Rodrigues, J Kim Dale

¹Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal.

Advances in Experimental Medicine and Biology

|September 12, 2008

Summary

This summary is machine-generated.

Embryonic development relies on precise temporal control, with somite formation being a key time-dependent event regulated by an intrinsic molecular clock. This segmentation clock mechanism is crucial for vertebrate body segmentation and is increasingly observed in other embryonic structures.

Related Experiment Videos

Last Updated: Jul 1, 2026

Mouse Embryonic Development in a Serum-free Whole Embryo Culture System

Mouse Embryonic Development in a Serum-free Whole Embryo Culture System

Published on: March 1, 2014

Area of Science:

Developmental biology
Molecular biology
Embryogenesis

Background:

Temporal control is crucial for embryonic development, dictating molecular patterning.
Somite formation is a fundamental, time-dependent event in embryogenesis, establishing the vertebrate segmented framework.
Previous models for somite periodicity lacked molecular evidence.

Purpose of the Study:

To review the mechanisms regulating somite periodicity.
To highlight the discovery and complexity of the molecular segmentation clock.
To explore the role of oscillating gene expression in embryonic development.

Main Methods:

Review of existing literature on somite formation and segmentation clocks.
Analysis of evidence for oscillating gene expression in embryonic tissues.
Synthesis of data on molecular mechanisms underlying temporal control in embryogenesis.

Main Results:

The formation of somites is regulated by an intrinsic molecular clock, evidenced by oscillating gene expression.
Since 1997, extensive data has revealed the complex molecular machinery of the segmentation clock.
Oscillating gene expression is also observed in embryonic structures beyond somites, suggesting broader roles.

Conclusions:

The segmentation clock is a fundamental mechanism for embryonic development and body segmentation.
The discovery of oscillating gene expression has significantly advanced our understanding of temporal control in embryogenesis.
Further research is needed to fully elucidate the diverse molecular mechanisms governing time control in embryonic development.