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Updated: Jun 26, 2026

A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro

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Root resorption and the OPG/RANKL/RANK system: a mini review.

Joanna B Tyrovola¹, Meropi N Spyropoulos, Margarita Makou

¹Department of Orthodontics, School of Dentistry, University of Athens, Athens, Greece. itirov@dent.uoa.gr

Journal of Oral Science

|December 25, 2008

Summary

The OPG/RANKL/RANK system influences orthodontic tooth movement and root resorption. Measuring serum OPG and s-RANKL may predict bone remodeling and root resorption rates during treatment.

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Area of Science:

Biomedical Science
Orthodontics
Cell Biology

Background:

Odontoclastic root resorption is a clinical concern in orthodontics and primary tooth development.
The OPG/RANKL/RANK system is implicated in alveolar bone remodeling and root resorption.
Serum OPG and s-RANKL levels may indicate bone homeostasis and remodeling activity.

Purpose of the Study:

To investigate the role of the OPG/RANKL/RANK system in orthodontic root resorption.
To determine if serum OPG and s-RANKL concentrations can predict root resorption during orthodontic tooth movement.

Main Methods:

Utilizing a carefully designed experimental study in healthy animals.
Measuring serum and gingival crevicular fluid (GCF) levels of OPG and s-RANKL.
Correlating these levels with the degree of root resorption during orthodontic tooth movement.

Main Results:

The OPG/RANKL/RANK system plays a role in both orthodontic and physiological root resorption.
Serum OPG and s-RANKL concentrations are linked to bone remodeling rates.
These markers may help predict the extent of root resorption during orthodontic treatment.

Conclusions:

Serum OPG and s-RANKL are potential biomarkers for predicting root resorption during orthodontic tooth movement.
Understanding this system can lead to better management of orthodontic treatment side effects.
Further research is warranted to validate these findings in clinical settings.