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Tetherless thermobiochemically actuated microgrippers.

Timothy G Leong1, Christina L Randall, Bryan R Benson

  • 1Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA.

Proceedings of the National Academy of Sciences of the United States of America
|January 14, 2009
PubMed
Summary
This summary is machine-generated.

We developed mass-producible, tetherless microgrippers that respond to temperature and chemicals. These microgrippers can be activated simultaneously for diverse applications, including cell removal for in vitro biopsies.

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Area of Science:

  • Biotechnology
  • Materials Science
  • Robotics

Background:

  • Tethered microgrippers require external connections, limiting their operational flexibility and scalability.
  • Remote triggering of micro-devices under biological conditions presents significant challenges.

Purpose of the Study:

  • To demonstrate mass-producible, tetherless microgrippers.
  • To enable remote triggering of microgrippers using temperature and chemical stimuli.
  • To showcase the application of these microgrippers in biological contexts.

Main Methods:

  • Development of microgrippers with self-contained actuation mechanisms.
  • Remote triggering protocols utilizing thermal and chemical cues.
  • In vitro demonstrations including bead manipulation and cell extraction from tissue.

Main Results:

  • Successful fabrication of mass-producible, tetherless microgrippers.
  • Demonstration of remote, simultaneous actuation of microgrippers via temperature and chemical signals.
  • Proof-of-concept applications in precise manipulation and minimally invasive cell retrieval.

Conclusions:

  • Tetherless microgrippers offer a versatile and scalable solution for micro-manipulation tasks.
  • Remote triggering capabilities enhance the utility of microgrippers in biologically relevant settings.
  • These microgrippers show promise for applications such as in vitro diagnostics and targeted cell sampling.