Related Experiment Video
Updated: Jun 25, 2026

Efficient Synthesis of Polyfunctionalized Benzenes in Water via Persulfate-promoted Benzannulation of α,β-Unsaturated Compounds and Alkynes
Published on: December 16, 2019
Cycloadditions of 1,1-disubstituted benzocyclobutenes obtained by C(sp3)-H activation
Manon Chaumontet1, Pascal Retailleau, Olivier Baudoin
1Institut de Chimie des Substances Naturelles, CNRS UPR2301, Avenue de la Terrasse, 91198 Gif-sur-Yvette, France.
Abstract:
An efficient synthesis of polycyclic molecules has been performed by a sequence involving palladium-catalyzed C-H activation and [4 + 2] cycloaddition. The intermediate benzocyclobutenes underwent a microwave-enhanced electrocyclic ring-opening/cycloaddition process with complete torquoselectivity and diastereoselectivity.
More Related Videos
07:50Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
10:10Application of Elemental Lanthanides in the Selective C-F Activation of Trifluoromethylated Benzofulvenes Providing Access to Various Difluoroalkenes
Published on: July 28, 2018
Related Concept Videos
Cycloaddition Reactions: MO Requirements for Thermal Activation
Cycloaddition Reactions: Overview
Nucleophilic Aromatic Substitution: Elimination–Addition
Electrophilic 1,2- and 1,4-Addition of X2 to 1,3-Butadiene
Cycloaddition Reactions: MO Requirements for Photochemical Activation
Electrophilic 1,2- and 1,4-Addition of HX to 1,3-Butadiene