[Effect of alpha/beta-interferon on electrophoretic mobility of murine T-lymphocytes]

Alpha/beta-Interferon (alpha/beta-IFN)-induced early changes in the electrophoretic mobility (EPM) of murine splenic T lymphocytes were studied by the microelectrophoresis technique. It has been found that alpha/beta-IFN-treated T lymphocytes have a greater EPM than control cells within first hours of alpha/beta-IFN addition. This change in EPM depends on the concentration of alpha/beta-IFN in the medium and the duration of alpha/beta-IFN interaction with the cells. It is concluded that the alpha/beta-IFN-treated cells have a greater net negative charge of the cell surface than control cells.