Related Experiment Video
Updated: May 27, 2026
High Throughput Single-cell and Multiple-cell Micro-encapsulation
Published on: June 15, 2012
Clinical outcomes of sirolimus-eluting stenting after rotational atherectomy
Hiromichi Tamekiyo1, Yasuhiko Hayashi, Mamoru Toyofuku
1Department of Cardiology, Tsuchiya General Hospital, Hiroshima, Japan. tame0214@yahoo.co.jp
Background:
The efficacy of drug-eluting stents after rotational atherectomy (ROTA) has not been clarified.
Methods And Results:
The 704 consecutive patients who underwent percutaneous coronary intervention (PCI) with a sirolimus-eluting stent (SES) (79 with and 625 without ROTA) were enrolled. The 2-year clinical outcome of these patients was compared with that of a group of 1,123 consecutive patients treated with bare-metal stents (BMS) (144 with and 979 without ROTA). At 2 years after index PCI, the use of SES after ROTA was associated with a lower crude incidence of major adverse cardiac events (MACE) than were BMS after ROTA (30.1% vs 43.1%, P=0.024). The difference was mainly derived from the reduction in target lesion revascularization (TLR) (25.0% vs 39.1%, P=0.022). After adjusting for confounders, ROTA-SES was associated with a reduction in MACE and TLR, with a similar hazard ratio to the non-ROTA group only with SES implantation. In a subgroup of dialysis patients, the incidence of TLR after ROTA with SES and BMS was similarly high.
Conclusions:
The use of SES after ROTA is an appropriate method for selected hard lesions, but has a limited effect in dialysis patients, even after lesion preparation with ROTA.
