Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sleep problems in subacute myelo-optico neuropathy (SMON).

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2019
Same author

Spastic Paraplegia Accompanied by Extrapyramidal Sign and Frontal Cognitive Dysfunction.

Internal medicine (Tokyo, Japan)·2019
Same author

Aural stimulation with capsaicin prevented pneumonia in dementia patients.

Auris, nasus, larynx·2019
Same author

Long-Term Stable Lithium Metal Anode in Highly Concentrated Sulfolane-Based Electrolytes with Ultrafine Porous Polyimide Separator.

ACS applied materials & interfaces·2019
Same author

A Unique Recurrent Stroke Case due to Bilateral Vertebral Artery Dissection with Familial Hirschsprung Disease.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2019
Same author

Clinical and Pathological Benefit of Twendee X in Alzheimer's Disease Transgenic Mice with Chronic Cerebral Hypoperfusion.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2019
Same journal

[Neuropathological Autopsies in Japan: Current Scenario and Challenges].

Brain and nerve = Shinkei kenkyu no shinpo·2026
Same journal

[Telemedicine and Digital Technologies in Neurological Intractable Diseases].

Brain and nerve = Shinkei kenkyu no shinpo·2026
Same journal

[Disaster Countermeasures for Intractable Neurological Disease].

Brain and nerve = Shinkei kenkyu no shinpo·2026
Same journal

[Supporting Health Care Transition for Patients with Childhood-Onset Chronic Conditions: Within Intractable Disease Care in Japan].

Brain and nerve = Shinkei kenkyu no shinpo·2026
Same journal

[Multidisciplinary Collaboration between Hospitals and Clinics at the University Hospital and the Core Hospital for the Treatment of Intractable Diseases].

Brain and nerve = Shinkei kenkyu no shinpo·2026
Same journal

[The Role of Coordinators for Intractable Diseases in Japan].

Brain and nerve = Shinkei kenkyu no shinpo·2026
See all related articles

Related Experiment Video

Updated: Jun 19, 2026

Embryonic Stem Cell-Derived Endothelial Cells for Treatment of Hindlimb Ischemia
09:11

Embryonic Stem Cell-Derived Endothelial Cells for Treatment of Hindlimb Ischemia

Published on: January 23, 2009

[Gene-stem Cell therapy for ischemic stroke].

Koji Abe1

  • 1Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.

Brain and Nerve = Shinkei Kenkyu No Shinpo
|October 7, 2009
PubMed
Summary
This summary is machine-generated.

Glial cell line-derived neurotrophic factor (GDNF) offers neuroprotection against ischemic brain damage by inhibiting cell death, independent of blood flow restoration. GDNF also enhances neural stem cell migration for potential regenerative therapies.

More Related Videos

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia
14:53

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia

Published on: June 26, 2020

Related Experiment Videos

Last Updated: Jun 19, 2026

Embryonic Stem Cell-Derived Endothelial Cells for Treatment of Hindlimb Ischemia
09:11

Embryonic Stem Cell-Derived Endothelial Cells for Treatment of Hindlimb Ischemia

Published on: January 23, 2009

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia
14:53

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia

Published on: June 26, 2020

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Regenerative Medicine

Context:

  • Acute stroke treatment requires both blood flow restoration and neuroprotection.
  • Neurotrophic factors (NTFs) and free radical scavengers show neuroprotective potential.
  • Glial cell line-derived neurotrophic factor (GDNF) has demonstrated efficacy in preclinical stroke models.

Purpose:

  • To evaluate the neuroprotective effects of GDNF against ischemic brain damage.
  • To investigate the impact of GDNF on cell death pathways and cerebral blood flow.
  • To explore the potential of NTFs in enhancing neural stem cell-based regenerative therapies for brain repair.

Summary:

  • Topical GDNF application reduced infarct size and brain edema in a rat middle cerebral artery occlusion model, without altering cerebral blood flow.
  • GDNF administration via Sendai virus vectors decreased infarct volume and inhibited apoptosis-inducible factor translocation.
  • NTFs significantly enhanced neural stem cell migration into artificial scaffolds, suggesting a strategy for promoting repair in chronic ischemic brain damage.

Impact:

  • GDNF provides direct neuroprotection against ischemic injury, highlighting its therapeutic potential.
  • Gene therapy with GDNF may offer a novel approach to stroke treatment by reducing apoptosis.
  • Combining NTFs with neural stem cell transplantation and scaffolds presents a promising avenue for future regenerative brain repair strategies.