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BLOOD FIBRIN IN UPPER GASTROINTESTINAL TRACT OBSTRUCTION
The Journal of Experimental Medicine
|October 30, 2009
Summary
High gastrointestinal tract obstruction causes a rapid increase in blood fibrin, particularly with stomach cardiac end blockages. This fibrin rise correlates with toxemia, suggesting liver failure is not the cause of death in these cases.
Area of Science:
- Gastroenterology
- Hematology
- Toxicology
Background:
- High gastrointestinal tract obstruction is a critical condition.
- Toxemia is a known complication of gastrointestinal obstruction.
- The role of blood fibrin in obstruction-related toxemia requires clarification.
Purpose of the Study:
- To investigate the changes in blood fibrin levels following high gastrointestinal tract obstruction.
- To determine if the location of obstruction influences fibrin levels.
- To correlate fibrin level changes with the severity of toxemia.
Main Methods:
- Induction of high gastrointestinal tract obstruction in animal models.
- Measurement of blood fibrinogen levels.
- Assessment of toxemia indicators.
Main Results:
- A rapid increase in blood fibrin was observed after high gastrointestinal tract obstruction.
- The fibrin increase was more pronounced with obstruction at the cardiac end of the stomach.
- Elevated fibrin levels closely paralleled the development of toxemia.
Conclusions:
- Blood fibrin levels significantly increase following high gastrointestinal tract obstruction.
- The cardiac end of the stomach appears to be a critical site for this response.
- Liver insufficiency is unlikely to be the primary cause of mortality in these obstruction scenarios.
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