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Updated: Jun 19, 2026
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Measuring Local Anaphylaxis in Mice
Published on: October 14, 2014
EXPERIMENTS ON ANAPHYLAXIS TO AZOPROTEINS : THIRD PAPER.
1Laboratories of The Rockefeller Institute for Medical Research.
The Journal of Experimental Medicine
|October 30, 2009
Summary
Specificity in anaphylactic reactions was observed using azoproteins with d- and l-tartaric acid isomers. Desensitization, achieved through specific azodye injection, prevented anaphylactic shock in tested animals.
Area of Science:
- Immunology
- Biochemistry
Background:
- Anaphylaxis is a severe allergic reaction.
- Stereochemistry plays a role in biological recognition.
Purpose of the Study:
- To investigate the specificity of anaphylactic reactions to stereoisomeric antigens.
- To explore desensitization as a method to prevent anaphylactic shock.
Main Methods:
- Utilized azoproteins with d- and l-tartaric acid isomeric groups as antigens.
- Conducted anaphylactic reaction experiments and precipitin tests.
- Administered specific azodye injections for desensitization.
Main Results:
- Demonstrated marked specificity in anaphylactic reactions based on stereochemistry.
- Precipitin tests confirmed the observed specificity.
- Successful prevention of anaphylactic shock through desensitization.
Conclusions:
- Anaphylactic reactions exhibit stereochemical specificity.
- Desensitization using specific antigens is an effective method to prevent anaphylactic shock.
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