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Anaphase Promoting Complex

Anaphase Promoting Complex

The stepwise destruction of specific proteins is necessary for the progression and completion of the cell cycle. Such proteins are ubiquitinated by ubiquitin ligases and then subsequently destroyed by the proteasome. The SCF (Skp1/Cullin/F-box) and the anaphase-promoting complex (APC) are two important ubiquitin ligases involved in cell cycle progression. While SCF is active throughout the cell cycle, APC gets activated during metaphase to anaphase transition. Cdc20 or Cdh1 binds to APC and...

Anaphase Promoting Complex

Anaphase Promoting Complex

The stepwise destruction of specific proteins is necessary for the progression and completion of the cell cycle. Such proteins are ubiquitinated by ubiquitin ligases and then subsequently destroyed by the proteasome. The SCF (Skp1/Cullin/F-box) and the anaphase-promoting complex (APC) are two important ubiquitin ligases involved in cell cycle progression. While SCF is active throughout the cell cycle, APC gets activated during metaphase to anaphase transition. Cdc20 or Cdh1 binds to APC and...

Antigen Presenting Cells

Antigen Presenting Cells

The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...

Combined Effects of Drugs: Antagonism

Combined Effects of Drugs: Antagonism

The combined effects of drugs can result in various interactions, of which an important type is antagonism. Antagonism is a mechanism where one drug inhibits or counteracts the effects of another drug. Antagonism can occur through various means, including receptor binding, allosteric modulation, functional interaction, chemical reactions, and pharmacokinetic processes.
The most common type is receptor antagonism, where one drug acts as an antagonist to block the effects of another drug by...

Epistasis

Epistasis

In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...

Pharmacokinetics: Drug–Drug Interactions

Pharmacokinetics: Drug–Drug Interactions

Drug interactions occur when the pharmacological effect of one drug is altered by another substance, either enhancing or diminishing its activity. The drug whose activity is altered is known as the object drug, and the substance causing the alteration is called the agent drug or the precipitant. The net effects of these interactions are mostly undesirable, leading to decreased effectiveness or increased adverse effects. In rare cases, interactions can be beneficial, such as the enhanced...

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Artificial Antigen Presenting Cell (aAPC) Mediated Activation and Expansion of Natural Killer T Cells

Artificial Antigen Presenting Cell (aAPC) Mediated Activation and Expansion of Natural Killer T Cells

Published on: December 29, 2012

The APC-EB1 interaction.

Ewan E Morrison¹

¹CRUK Clinical Centre at Leeds, Leeds Institute of Molecular Medicine, St James's University Hospital, Leeds, UK. e.e.morrison@leeds.ac.uk

Advances in Experimental Medicine and Biology

|November 26, 2009

Summary

This summary is machine-generated.

Adenomatous polyposis coli (APC) gene mutations disrupt WNT signaling and impact colorectal cancer cell behavior. The interaction between APC and EB1 proteins is crucial for cell migration and mitosis, affecting both normal and cancerous cells.

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An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

Area of Science:

Cell Biology
Molecular Biology
Oncology

Background:

Adenomatous polyposis coli (APC) gene mutations are linked to colorectal cancer development.
Mutant APC proteins lose the ability to regulate WNT signaling and interact with other ligands.
The microtubule plus-end binding protein EB1 is an APC binding partner involved in microtubule dynamics.

Purpose of the Study:

To review the functional role of the APC-EB1 interaction in cellular processes.
To explore the implications of the APC-EB1 interaction in normal epithelial and colorectal cancer cells.

Main Methods:

Literature review of studies on APC and EB1 interactions.
Analysis of the role of APC-EB1 in cell migration and mitosis.
Examination of the impact on colorectal tumor development.

Main Results:

The APC-EB1 interaction is involved in regulating microtubule dynamics.
This interaction plays a role in directed cell migration and mitosis.
Dysregulation of the APC-EB1 interaction may contribute to colorectal tumorigenesis.

Conclusions:

The APC-EB1 interaction is a significant factor in cellular functions relevant to colorectal cancer.
Understanding this interaction offers potential therapeutic targets for colorectal tumors.