Related Experiment Video
Updated: Jun 18, 2026

Restraint to Induce Stress in Mice and Rats
Published on: December 6, 2024
Physical and chemical restraints.
Victoria A Coburn1, Mark B Mycyk
1Department of Emergency Medicine, Boston University School of Medicine, Boston Medical Center, 1 Boston Medical Center Place, Dowling 1 South, Boston, MA 02118, USA.
Managing combative patients in emergency departments is crucial. This article reviews de-escalation techniques and the risks associated with physical and chemical restraints for patient safety.
Area of Science:
- Emergency Medicine
- Patient Safety
- Behavioral Health
Background:
- Combative or uncooperative patient behavior presents a significant challenge in emergency departments.
- Restraint use in these patients increases the risk of adverse outcomes.
- De-escalation techniques are increasingly emphasized to minimize restraint necessity.
Purpose of the Study:
- To examine de-escalation techniques for managing agitated patients.
- To review the indications for and risks of physical and chemical restraints.
- To inform best practices in emergency department patient management.
Main Methods:
- Literature review of de-escalation strategies.
- Analysis of evidence regarding physical restraint risks.
- Examination of chemical restraint protocols and safety.
Main Results:
- De-escalation is a primary strategy to reduce restraint use.
- Physical restraints carry inherent risks, including injury and psychological distress.
- Chemical restraints require careful consideration of medication, dosage, and monitoring.
Conclusions:
- Effective de-escalation is key to improving emergency department safety.
- Judicious use of restraints, when necessary, must prioritize patient well-being.
- Further research into optimal restraint and de-escalation protocols is warranted.
More Related Videos
Related Concept Videos
Physical and Chemical Properties of Matter
Specialized Care Centers and Settings-II
Rural health centers are specialized care facilities in remote locations with very few medical personnel. The primary care providers who run the centers are mostly Registered Nurse Practitioners. Here, emergency treatment is provided to critically ill or injured patients before they are transferred to the closest hospital. Fortunately, due to advancement in technology, many rural healthcare facilities and professionals have easy access to diagnostic and treatment...
Spasmolytic Agents: Chemical Classification
A major class of centrally acting spasmolytics is the α2-agonist, such as tizanidine. These drugs bind to α2-adrenoceptors, inhibiting the release of the excitatory neurotransmitter glutamate. They also promote...
Chemical Reactions
Chemical Reactions Rearrange Atoms into New Substances
A chemical reaction takes starting materials—the reactants—and changes them into different...
Chemical Reactions
The relative amounts of reactants and products represented in a balanced chemical equation are often referred to as stoichiometric amounts. However, in...
Skeletal Muscle Relaxants: Therapeutic Uses

