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Related Concept Videos

Conjugated Proteins02:50

Conjugated Proteins

Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
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Peptide Bonds02:43

Peptide Bonds

A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
Polymers02:34

Polymers

The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the properties that they exhibit. Additionally,...
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Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...

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Updated: Jun 17, 2026

Synthesis of Protein Bioconjugates via Cysteine-maleimide Chemistry
09:14

Synthesis of Protein Bioconjugates via Cysteine-maleimide Chemistry

Published on: July 20, 2016

Polypeptide-polymer bioconjugates.

Luiz A Canalle1, Dennis W P M Löwik, Jan C M van Hest

  • 1Bio-Organic Chemistry, Institute for Molecules and Materials, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.

Chemical Society Reviews
|December 22, 2009
PubMed
Summary
This summary is machine-generated.

This review explores strategies for creating polymer-peptide and polymer-protein bioconjugates. It details synthetic methods for controlled construction of these advanced materials for various scientific applications.

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Last Updated: Jun 17, 2026

Synthesis of Protein Bioconjugates via Cysteine-maleimide Chemistry
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OaAEP1-Mediated Enzymatic Synthesis and Immobilization of Polymerized Protein for Single-Molecule Force Spectroscopy

Published on: February 5, 2020

Area of Science:

  • Bioconjugation Chemistry
  • Polymer Science
  • Materials Science

Background:

  • Bioconjugates combining polymers with peptides and proteins are gaining research interest.
  • These materials offer unique properties for diverse applications.

Purpose of the Study:

  • To provide a comprehensive overview of strategies for constructing polypeptide-polymer bioconjugates.
  • To highlight the synthetic methodologies used in creating these advanced materials.

Main Methods:

  • Literature review of existing research on bioconjugate synthesis.
  • Analysis of various chemical strategies for polymer-peptide and polymer-protein conjugation.

Main Results:

  • Detailed examination of different approaches for controlled bioconjugate formation.
  • Identification of key synthetic routes and their advantages.

Conclusions:

  • The field of polypeptide-polymer bioconjugates is rapidly advancing.
  • Controlled synthesis is crucial for developing tailored materials for chemists, material scientists, and chemical biologists.