Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Problem-Solving: Tuning of a Guitar String01:04

Problem-Solving: Tuning of a Guitar String

In the case of stringed instruments like the guitar, the elastic property that determines the speed of the sound produced is its linear mass density or the mass per unit length. This is simply called the linear density. If the string's linear density is constant along the string, then the linear density is simply the total mass divided by the total length.
The string's wave speed can be regulated by varying the linear density. Tension is the other property that determines the speed of...
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the ATP-dependent...
Upsampling01:22

Upsampling

Managing signal sampling rates is essential in digital signal processing to maintain signal integrity. A decimated signal, characterized by a reduced frequency range due to its lower sampling rate, can be upsampled by inserting zeros between each sample. This upsampling process expands the original spectrum and introduces repeated spectral replicas at intervals dictated by the new Nyquist frequency. To refine this zero-inserted sequence, it is passed through a lowpass filter with a cutoff...
Experimental RNAi02:15

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
Biasing of FET01:22

Biasing of FET

Biasing a Junction Field Effect Transistor (JFET) is crucial for setting operational parameters and ensuring efficient functioning in electronic circuits. JFETs are characterized by using a single carrier type in N-channel or P-channel configurations, where the channel is surrounded by PN junctions. These junctions are central to the device's ability to control current flow.
In an N-channel JFET, the structure consists of N-type material forming the channel on a P-type substrate, with the gate...
Parallel Resonance01:23

Parallel Resonance

The parallel RLC circuit is an arrangement where the resistor (R), inductor (L), and capacitor (C) are all connected to the same nodes and, as a result, share the same voltage across them. The parallel RLC circuit is analyzed in terms of admittance (Y), which reflects the ease with which current can flow. The admittance is given by:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Histone 3 lysine 9 dimethylation by the G9a-GLP heterodimer requires intranucleosomal product reading.

bioRxiv : the preprint server for biology·2026
Same author

The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate.

Nature cell biology·2025
Same author

<i>O</i>-GlcNAc modifications regulate lamin A tail processing.

bioRxiv : the preprint server for biology·2025
Same author

Aging activates escape of the silent X chromosome in the female mouse hippocampus.

Science advances·2025
Same author

The maternal X chromosome affects cognition and brain ageing in female mice.

Nature·2025
Same author

The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate.

bioRxiv : the preprint server for biology·2024
Same journal

Psychological stress drives aging-like hematopoietic stem cell dysfunction through a brain-gut-bone marrow axis.

Cell stem cell·2026
Same journal

Human stem cell-based embryo model governance: Insights from Japan.

Cell stem cell·2026
Same journal

From reconstruction to intervention: Engineered organoids as living therapeutic depots.

Cell stem cell·2026
Same journal

Long-term lessons from MATCH01 macrophage therapy in cirrhosis.

Cell stem cell·2026
Same journal

Beyond apoptosis: LSC state dictates metabolic and anti-apoptotic vulnerabilities.

Cell stem cell·2026
Same journal

Outside the niche: Gut microbiota relay psychological stress to hematopoietic stem cell dysfunction.

Cell stem cell·2026
See all related articles

Related Experiment Video

Updated: Jun 16, 2026

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
10:44

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing

Published on: May 5, 2023

Fine-tuning silencing.

Barbara Panning1

  • 1Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA. barbara.panning@ucsf.edu

Cell Stem Cell
|January 21, 2010
PubMed
Summary
This summary is machine-generated.

Polycomb Repressive Complex 2 (PRC2) silences embryonic genes. A new component, Jarid2/Jumonji, was identified, which fine-tunes this silencing by inhibiting PRC2 enzymatic activity.

More Related Videos

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
09:43

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Published on: October 31, 2013

Design and Characterization Methodology for Efficient Wide Range Tunable MEMS Filters
15:25

Design and Characterization Methodology for Efficient Wide Range Tunable MEMS Filters

Published on: February 4, 2018

Related Experiment Videos

Last Updated: Jun 16, 2026

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
10:44

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing

Published on: May 5, 2023

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
09:43

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Published on: October 31, 2013

Design and Characterization Methodology for Efficient Wide Range Tunable MEMS Filters
15:25

Design and Characterization Methodology for Efficient Wide Range Tunable MEMS Filters

Published on: February 4, 2018

Area of Science:

  • Epigenetics and gene regulation
  • Developmental biology
  • Molecular mechanisms of gene silencing

Background:

  • Polycomb Repressive Complex 2 (PRC2) is crucial for gene silencing during embryonic development.
  • PRC2 activity restricts gene expression to specific cell populations, ensuring proper development.
  • Dysregulation of PRC2 can lead to developmental abnormalities.

Purpose of the Study:

  • To identify novel components of the PRC2 complex.
  • To elucidate the regulatory mechanisms of PRC2 enzymatic activity.
  • To understand how PRC2 contributes to the precise control of gene expression in development.

Main Methods:

  • Biochemical assays to characterize protein interactions within PRC2.
  • Enzymatic assays to measure PRC2 activity.
  • Gene expression analysis in embryonic cells.

Main Results:

  • Identification of Jarid2/Jumonji as a novel component of PRC2.
  • Demonstration that Jarid2 inhibits the enzymatic activity of PRC2.
  • Fine-tuning of gene silencing by Jarid2-mediated inhibition of PRC2.

Conclusions:

  • Jarid2 is a key regulator of PRC2 function.
  • PRC2 activity is modulated by its components to achieve precise gene silencing.
  • This regulation is essential for normal embryonic development.