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Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability
Published on: August 6, 2021
Serous retinal detachment associated with retinal vein occlusion
Akitaka Tsujikawa1, Atsushi Sakamoto, Masafumi Ota
1Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan. tujikawa@kuhp.kyoto-u.ac.jp
American Journal of Ophthalmology
|January 28, 2010
Summary
Serous retinal detachment in retinal vein occlusion often starts as a pointed shape under the fovea and can evolve into a dome shape. Optical coherence tomography reveals Müller cell cone involvement in its formation.
Area of Science:
- Ophthalmology
- Medical Imaging
- Retinal Diseases
Background:
- Macular edema is a common complication of retinal vein occlusion.
- Optical coherence tomography (OCT) is crucial for visualizing retinal structures.
Purpose of the Study:
- To investigate the pathomorphology of serous retinal detachment (RD) in eyes with retinal vein occlusion using OCT.
- To understand the structural changes associated with serous RD in this patient group.
Main Methods:
- Retrospective chart review of 91 patients with macular edema due to retinal vein occlusion.
- Comprehensive ophthalmologic examination including spectral-domain OCT measurements.
Main Results:
- Eighty-three percent of eyes exhibited serous RD involving the fovea, with varying thickness.
- A small, pointed RD beneath the fovea was observed, often progressing to a dome-shaped RD.
- Retinal swelling, particularly in the outer retina, and foveal cystoid spaces were common findings.
Conclusions:
- Serous RD in retinal vein occlusion may initially present as a pointed shape and transform into a dome shape.
- The study hypothesizes that foveal architecture, specifically the Müller cell cone, plays a role in serous RD formation.
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