[The effect of desmopressin on changes of bile acids specter in rats]

We studied the effect of the synthetic analogue of antidiuretic hormone-desmopressin on the level of choleresis and the bile acids spectrum in acute experiments in bile duct-cannulated rats. It is shown that desmopressin increases bile flow and concentration of taurin-conjugated bile acids. In this situation, the concentration ofglycocholates practically is not changed, and concentration of free bile acids is diminished, which results in increase in the conjugation coefficient. Blockade of V(1a) vasopressin receptors decreases the efficiency of desmopressin regulatory effect on certain aspects of bile secretion. Indexes of choleresis volume velocity were less than those obtained following peptide introduction. The changes in concentration of conjugated and free bile acids had opposite dynamics. Concentration of tauro- and glycocholates was diminished, while concentration of free bile acids was increased, which resulted in a decrease in conjugation coefficient. The data obtained indicate that desmopressin affects both the synthesis and in a higher degree the conjugation process of bile acids with amino acids through V(1a) vasopressin receptors.