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Intraoperative Visualization of Subretinal Injection and Retinal Detachment in Rats
Published on: March 7, 2025
Oxane HD and retinal detachment surgery in routine clinical practice
Ghee Soon Ang1, Anna Louise Murphy, Wai Siene Ng
1Department of Ophthalmology, Aberdeen Royal Infirmary, Aberdeen, UK.
Summary
Oxane HD shows utility in inferior retinal detachment repair but has a high emulsification rate. Prior use of perfluorodecalin, especially direct exchange, may increase intraocular complications.
Area of Science:
- Ophthalmology
- Retinal Surgery
- Vitreoretinal Interface
Background:
- Inferior retinal detachment presents unique surgical challenges.
- Oxane HD is an endotamponade agent used in retinal detachment repair.
- Vitreoretinal surgery outcomes are influenced by tamponade agents and intraoperative techniques.
Purpose of the Study:
- To evaluate the outcomes and complications of using Oxane HD as an endotamponade.
- To assess the impact of prior perfluorodecalin use on Oxane HD outcomes.
- To determine the safety and efficacy of Oxane HD in complex retinal detachments.
Main Methods:
- Retrospective consecutive case series analysis.
- Inclusion of patients with inferior retinal detachment treated with Oxane HD.
- Review of 18 eyes over a 3-year period, analyzing success rates and complications.
Main Results:
- Anatomic success rate of 77.8% for retinal detachment repair with Oxane HD.
- High postoperative complication rate (77.8%), notably emulsification (33.3%).
- Increased complications observed with prior intraoperative perfluorodecalin use (85.7%), particularly direct exchange (100%).
Conclusions:
- Oxane HD is effective for inferior retinal detachments but carries a significant risk of emulsification.
- Intraoperative perfluorodecalin use, especially direct exchange with Oxane HD, is linked to higher complication rates.
- Further research is needed to optimize tamponade strategies and minimize complications in complex retinal detachments.

