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Related Concept Videos

The Contractile Ring02:15

The Contractile Ring

Contractile rings are composed of microfilaments and are responsible for separating the daughter cells during cytokinesis. Contractile ring assembly proceeds along with other cell cycle events; however, very few mechanistic details are known about the timing and coordination of the contractile rings with the cell cycle.
A small GTPase, RhoA, controls the function and assembly of the contractile ring. RhoA belongs to the Ras superfamily of proteins. The activation of formins by RhoA promotes...
The Contractile Ring02:15

The Contractile Ring

Contractile rings are composed of microfilaments and are responsible for separating the daughter cells during cytokinesis. Contractile ring assembly proceeds along with other cell cycle events; however, very few mechanistic details are known about the timing and coordination of the contractile rings with the cell cycle.
A small GTPase, RhoA, controls the function and assembly of the contractile ring. RhoA belongs to the Ras superfamily of proteins. The activation of formins by RhoA promotes...
Separation of Sister Chromatids02:17

Separation of Sister Chromatids

At the transition from prophase to metaphase, there is a reduction in cohesion along the chromosomal arms, resulting in the resolution of sister chromatids. However, residual cohesin connections remain to hold the sister chromatids together until the transition from metaphase to anaphase. The residual connection prevents any premature separation of sister chromatids, blocking the risks of aneuploidy within the daughter cells.
At the onset of anaphase, separase, a proteolytic enzyme, is...
Separation of Sister Chromatids02:17

Separation of Sister Chromatids

At the transition from prophase to metaphase, there is a reduction in cohesion along the chromosomal arms, resulting in the resolution of sister chromatids. However, residual cohesin connections remain to hold the sister chromatids together until the transition from metaphase to anaphase. The residual connection prevents any premature separation of sister chromatids, blocking the risks of aneuploidy within the daughter cells.
At the onset of anaphase, separase, a proteolytic enzyme, is...
Mitosis and Cytokinesis01:35

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Mitosis and Cytokinesis02:03

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...

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Related Experiment Video

Updated: Jun 10, 2026

Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast
11:19

Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast

Published on: February 20, 2017

Understanding cytokinesis failure.

Guillaume Normand1, Randall W King

  • 1HTS Core Facility, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

Advances in Experimental Medicine and Biology
|August 7, 2010
PubMed
Summary
This summary is machine-generated.

Cytokinesis, the final step of cell division, involves intricate cellular processes that can fail, leading to tumor development. Understanding these mechanisms is crucial for cell biology and cancer research.

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Last Updated: Jun 10, 2026

Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast
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Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations
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Studying Mitotic Checkpoint by Illustrating Dynamic Kinetochore Protein Behavior and Chromosome Motion in Living Drosophila Syncytial Embryos
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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • Cytokinesis is the final stage of cell division, partitioning the cytoplasm.
  • It involves complex interactions between cytoskeletal, chromosomal, and regulatory pathways.
  • Failure in cytokinesis can lead to genomic instability and disease.

Purpose of the Study:

  • To summarize current understanding of cytokinesis mechanisms.
  • To highlight regulated and failure-prone steps in cytokinesis.
  • To emphasize findings in vertebrate cells while incorporating other model systems.

Main Methods:

  • Review of existing literature on cell division and cytokinesis.
  • Analysis of molecular and cellular pathways involved in cytokinesis.
  • Comparison of findings across different model organisms.

Main Results:

  • Cytokinesis requires coordinated efforts from multiple cellular processes, including trafficking, metabolism, and signaling.
  • Cytokinesis failure can result in centrosome amplification and tetraploidy.
  • Tetraploid cells are also found in normal tissues, indicating physiological regulation.

Conclusions:

  • Cytokinesis is a complex, highly regulated process essential for cell division.
  • Dysregulation of cytokinesis is linked to pathologies like cancer.
  • Further research into regulated and failure-prone steps is warranted.