Related Experiment Video
Updated: Jun 9, 2026
06:39
Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice
Published on: April 13, 2015
Aortic pressures, stiffness and left ventricular function in coronary slow flow phenomenon.
Halil Tanriverdi1, Harun Evrengul, I Dogu Kilic
1Department of Cardiology, Pamukkale University School of Medicine, Denizli, Turkey. drhaliltanriverdi@yahoo.com.tr
Cardiology
|August 28, 2010
Summary
Patients with coronary slow flow (CSF) exhibit impaired aortic elasticity and higher aortic pressures. This reduced aortic elasticity is linked to impaired left ventricular diastolic function in CSF patients.
Area of Science:
- Cardiology
- Vascular Physiology
- Diagnostic Imaging
Background:
- Coronary slow flow (CSF) is defined by delayed coronary vessel opacification on angiography.
- The pathophysiology of CSF remains incompletely understood.
- This study investigates aortic pressure, stiffness, and left ventricular function in CSF patients.
Purpose of the Study:
- To evaluate central aortic pressure in patients with coronary slow flow.
- To assess aortic stiffness and its relation to CSF.
- To determine left ventricular (LV) function in patients with CSF.
Main Methods:
- Invasive assessment of aortic pressures and elastic properties.
- Analysis of 154 patients (81 with CSF, 73 controls) with angina symptoms.
- Evaluation of LV Doppler parameters and correlation with aortic properties.
Main Results:
- CSF patients showed significantly higher aortic pulse pressure and pulsatility index compared to controls.
- Left ventricular Doppler parameters were impaired in patients with CSF.
- Aortic fractional pulse pressure and pulsality index correlated significantly with TIMI frame count and LV diastolic parameters.
Conclusions:
- Impaired aortic elasticity is a feature of coronary slow flow.
- Reduced aortic elasticity may contribute to impaired LV diastolic parameters in CSF patients.
Related Concept Videos
01:22Mitral Stenosis I: Introduction
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
01:22Aortic Regurgitation II: Clinical Features and Diagnostic Tests
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
01:15Aortic Regurgitation I: Introduction
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
01:23Mitral Stenosis II: Clinical features and Diagnostic Tests
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
01:24Cardiac Catheterization III: Left Heart Catheterization
Left heart catheterization is an invasive diagnostic procedure used to evaluate the function and structure of the left side of the heart. It is generally performed to diagnose and treat cardiovascular conditions such as valve abnormalities, coronary artery disease, and congenital heart defects.Diagnostic and therapeutic purposesLeft heart catheterization serves various diagnostic and therapeutic purposes, including:Assessing coronary artery bypass grafts.Evaluating coronary artery disease in...