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Atypical multicentric reticulohistiocytosis.
R R Mittal1, S Gupta, P S Sethi
1From the Department of Dermato-Venereology, Rajindra Hospital, Patiala-147001, India, .
Indian Journal of Dermatology, Venereology and Leprology
|October 6, 2010
Summary
This case study highlights multicentric reticulohistiocytosis, a rare disease causing skin nodules and arthritis. It details unusual patient associations and treatment responses, offering insights into this complex condition.
Area of Science:
- Dermatology
- Rheumatology
- Pathology
Background:
- Multicentric reticulohistiocytosis (MRH) is a rare, non-Langerhans cell histiocytosis.
- It typically presents with arthritis and characteristic skin and systemic lesions.
Purpose of the Study:
- To report a unique case of MRH with unusual clinical associations.
- To discuss the histopathological confirmation and treatment response.
Main Methods:
- Clinical presentation review.
- Histopathological examination of skin biopsy.
- Analysis of patient history and treatment response.
Main Results:
- A 38-year-old male with an 8-year history of arthritis presented with erythematous papules, plaques, and nodules.
- Histopathology revealed multiple foreign body giant cells, confirming MRH.
- Unusual findings included tapered fingers with scarred tips, low erythrocyte sedimentation rate (ESR), and Raynaud's phenomenon.
- Lesions exacerbated after methotrexate treatment.
Conclusions:
- This case underscores the diverse and sometimes atypical presentations of MRH.
- The association with tapered fingers, low ESR, and Raynaud's phenomenon adds to the spectrum of MRH.
- Methotrexate's role in exacerbating lesions warrants further investigation in MRH management.
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