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A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
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Published on: April 2, 2012

Disseminated herpes zoster.

R R Mittal1,

  • 1Department of Dermatovenereology, Rajindra Hospital, Patiala, Punjab, India.

Indian Journal of Dermatology, Venereology and Leprology
|October 19, 2010
PubMed
Summary
This summary is machine-generated.

Disseminated herpes zoster (DHZ) cases, even with mild underlying conditions, typically resolve well. Most patients with DHZ do not require antiviral treatment and recover without lasting effects.

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Area of Science:

  • Dermatology
  • Virology
  • Infectious Diseases

Background:

  • Disseminated herpes zoster (DHZ) is a rare but serious manifestation of varicella-zoster virus reactivation.
  • Understanding DHZ in patients without severe immunosuppression is crucial for appropriate clinical management.

Purpose of the Study:

  • To describe the clinical characteristics and outcomes of disseminated herpes zoster patients.
  • To evaluate the need for antiviral therapy in non-immunosuppressed DHZ patients.

Main Methods:

  • Retrospective case series of eleven patients admitted with disseminated herpes zoster.
  • Review of patient demographics, clinical presentation, comorbidities, treatment, and outcomes.

Main Results:

  • Eleven patients with DHZ were identified between January 1992 and April 1995.
  • Patients presented with classical herpes zoster followed by aberrant vesicles on trunk, limbs, and face.
  • Comorbidities included diabetes mellitus, recent prednisolone use, anemia, and urinary tract infection; none had severe immunosuppression or malignancy.
  • Only one patient required oral acyclovir therapy.
  • All patients achieved complete recovery without sequelae.

Conclusions:

  • Disseminated herpes zoster can occur in individuals with mild or no significant immunosuppressive conditions.
  • DHZ in this patient group often resolves favorably with conservative management.
  • Antiviral therapy may not be necessary for all DHZ cases, particularly in the absence of severe immunosuppression.