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Updated: Jun 8, 2026
09:08
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
Published on: October 14, 2021
Pre-sezary To Sezary Erythroderma Syndrome
1From the Department of Dermato-Venereology, Government Medical College, Rajindra Hospital, Patiala-147001, India, .
Indian Journal of Dermatology, Venereology and Leprology
|October 6, 2010
Summary
Pre-Sezary syndrome, a rare skin condition, was treated with prednisolone alone without success. Combination therapy with prednisolone and chlorambucil effectively managed the patient's erythroderma and pruritus.
Area of Science:
- Dermatology
- Oncology
- Hematology
Background:
- Pre-Sezary syndrome is a rare T-cell lymphoproliferative disorder.
- It presents with erythroderma, intense pruritus, lymphadenopathy, and characteristic Sezary cells.
- Standard treatments often involve corticosteroids, but response can be variable.
Purpose of the Study:
- To report a case of pre-Sezary syndrome.
- To evaluate treatment response to monotherapy versus combination therapy.
Main Methods:
- A 50-year-old female patient presented with symptoms consistent with pre-Sezary syndrome.
- Initial treatment involved high-dose prednisolone monotherapy.
- Subsequent treatment utilized a combination of prednisolone and chlorambucil.
Main Results:
- Prednisolone monotherapy at 40 mg daily showed no significant improvement.
- Combination therapy with 20 mg prednisolone and 2.5 mg chlorambucil daily resulted in a favorable clinical response.
- The patient experienced resolution of erythroderma and pruritus.
Conclusions:
- Combination therapy of prednisolone and chlorambucil can be an effective treatment for pre-Sezary syndrome.
- This regimen offers a potential therapeutic option for patients refractory to corticosteroid monotherapy.
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