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Lipid-rich plaques predict non-target-lesion ischemic events in patients undergoing percutaneous coronary

Tetsuya Amano1, Tatsuaki Matsubara, Tadayuki Uetani

  • 1Department of Cardiology, Chubu-Rosai Hospital, Nagoya, Japan. amanot@med.nagoya-u.ac.jp

Circulation Journal : Official Journal of the Japanese Circulation Society
|December 1, 2010
PubMed

Insights

Lipid-rich plaques (LRP) and elevated C-reactive protein (CRP) predict non-target ischemic events after percutaneous coronary intervention (PCI). These factors, especially when combined, significantly increase patient risk following PCI procedures.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Vascular Ultrasound

Background:

  • Non-target lesion events after percutaneous coronary intervention (PCI) are of growing interest.
  • Predictors for these events remain under-discussed in clinical literature.

Purpose of the Study:

  • To identify independent predictors of non-target ischemic events following PCI.
  • To investigate the role of lipid-rich plaques (LRP) and C-reactive protein (CRP) in predicting these events.

Main Methods:

  • 155 patients undergoing PCI were analyzed.
  • Integrated backscatter intravascular ultrasound (IB-IVUS) assessed non-target lesions for lipid content.
  • Cox proportional hazard models identified predictors of non-target events.

Main Results:

  • Lipid-rich plaques (LRP), elevated serum C-reactive protein (CRP), and acute coronary syndrome at baseline were independent predictors of non-target events.
  • A synergistic effect was observed between LRP and elevated CRP in predicting non-target events (OR, 14.8).

Conclusions:

  • Integrated backscatter intravascular ultrasound-measured LRP is an independent morphologic predictor of non-target ischemic events post-PCI.
  • Elevated serum CRP levels significantly enhance the risk prediction of LRP for non-target events.
Abstract

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