Related Experiment Video
Updated: Jun 5, 2026

Refined Murine Model of Idiopathic Pulmonary Fibrosis
Published on: June 17, 2025
[Acute exacerbations of idiopathic pulmonary fibrosis]
Romain Lazor1, Alessandro Bonetti, Laurent P Nicod
1Service de pneumologie, CHUV, 1011 Lausanne. romain.lazor@chuv.ch
Abstract:
Although generally considered as a slowly evolving disease, idiopathic pulmonary fibrosis (IPF) is also characterized by episods of rapid deterioration with worsening of dyspnea and hypoxemia, and new ground glass opacities at imaging. These events called "acute exacerbations" (AE) are responsible for half of all deaths in IPF. Pathophysiologic mechanisms of AE are poorly understood. The effectiveness of corticosteroids and immunosuppressive agents appears limited. The mortality of AE is 60-70%. Preventing or controlling AE could improve the overall prognosis of IPF. AE also exist in other interstitial lung diseases.
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