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Association between selected folate pathway polymorphisms and nonsyndromic limb reduction defects: a case-parental

Mario A Cleves1, Charlotte A Hobbs, Weizhi Zhao

  • 1Arkansas Center for Birth Defects Research and Prevention, Department of Pediatrics, University of Arkansas for Medical Sciences, and Arkansas Children's Hospital Research Institute, Little Rock, AR 72202, USA. clevesmarioa@uams.edu

Paediatric and Perinatal Epidemiology
|February 2, 2011
PubMed
Summary

Maternal multivitamin use, particularly folic acid, may reduce the risk of limb reduction defects (LRDs). Offspring inheriting MTHFR 677T variants face higher LRD risk without maternal supplementation.

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