Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pharmacodynamics in Geriatric Patients: Effects of Age

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...

Drug Dosing: Geriatric Patients

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Arm-support exoskeleton reduces shoulder muscle activity in ceiling construction.

Ergonomics·2023

Same author

The effect of back muscle fatigue on EMG and kinematics based estimation of low-back loads and active moments during manual lifting tasks.

Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology·2023

Same author

Field study on the use and acceptance of an arm support exoskeleton in plastering.

Ergonomics·2022

Same author

What about the human in human robot collaboration?

Ergonomics·2021

Same author

Effect of horizontal pick and place locations on shoulder kinematics.

Ergonomics·2014

Same author

Validation of a dynamic linked segment model to calculate joint moments in lifting.

Clinical biomechanics (Bristol, Avon)·2013

Search research articles

Related Experiment Video

Updated: Jun 3, 2026

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

What is the evidence for less shift work tolerance in older workers?

M M Blok¹, M P de Looze

¹TNO, Hoofddorp, The Netherlands.

|March 11, 2011

Summary

Older workers show mixed tolerance to shift work, with some experiencing more issues on night shifts but fewer on morning shifts. Evidence does not fully support greater shift work problems in older individuals.

Area of Science:

Occupational Health
Human Factors Engineering
Gerontology

Background:

The tolerance of older individuals to shift work is a debated topic in occupational health.
Previous research has yielded inconsistent findings regarding age-related differences in shift work adaptation.

Purpose of the Study:

To systematically review existing literature on the interaction between age and shift work.
To evaluate the evidence supporting the hypothesis that older workers are less tolerant to shift work.

Main Methods:

A comprehensive review of field studies examining age-shift work interactions.
Analysis included effects on sleep, fatigue, performance, accidents, and health.
Studies compared shift workers with day workers and analyzed different shift types (morning, afternoon, night) and systems (rosters).

More Related Videos

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Published on: January 24, 2020

Related Experiment Videos

Last Updated: Jun 3, 2026

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Published on: January 24, 2020

Main Results:

Nine studies comparing shift and day workers showed mixed results: two indicated more problems for older workers, four showed the opposite, and five found no significant age-shift interaction.
Across-shift comparisons in six studies suggested older workers experience more sleep problems with night shifts but fewer with morning shifts compared to younger workers.
Overall, the review found limited evidence to support the notion that older workers inherently experience more shift work-related problems.

Conclusions:

While some age-specific differences in shift work tolerance exist, particularly concerning night and morning shifts, the evidence does not conclusively suggest greater overall intolerance in older workers.
The findings highlight a need for further research into the nuanced relationship between aging and shift work.
Age-specific considerations should be integrated into the planning of shift work schedules to optimize worker well-being and performance.