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Related Concept Videos

Magnetic Resonance Imaging01:24

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
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Published on: November 8, 2012

Apparent exchange rate mapping with diffusion MRI.

Samo Lasič1, Markus Nilsson, Jimmy Lätt

  • 1Division of Physical Chemistry, Department of Medical Radiation Physics, Lund University, Lund, Sweden. samo.lasic@fkem1.lu.se

Magnetic Resonance in Medicine
|March 30, 2011
PubMed
Summary
This summary is machine-generated.

This study introduces filter exchange imaging, a novel MRI method to measure water exchange across cell membranes. This technique can help diagnose diseases like tumors and stroke by assessing membrane changes.

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Area of Science:

  • Biophysics
  • Medical Imaging
  • Cell Biology

Background:

  • Water exchange across cell membranes is crucial for tissue function.
  • Altered membrane properties are linked to diseases like tumors, multiple sclerosis, and ischemic stroke.
  • Noninvasive methods to quantify water exchange are needed for disease characterization.

Purpose of the Study:

  • To develop and validate the filter exchange imaging (FEI) method for quantifying water exchange rates.
  • To adapt the filter-exchange pulsed gradient spin-echo NMR spectroscopy for clinical MRI scanners.
  • To assess the potential of FEI as a diagnostic tool for pathological conditions.

Main Methods:

  • Utilized a modified filter-exchange pulsed gradient spin-echo NMR spectroscopy experiment.
  • Developed a model-free approach for data analysis to generate apparent exchange rate maps.
  • Performed proof-of-principle experiments on microimaging and clinical whole-body MRI scanners using yeast phantoms.

Main Results:

  • Demonstrated the feasibility of filter exchange imaging on clinical MRI scanners.
  • Showcased the method's ability to map apparent water exchange rates.
  • Confirmed filter exchange imaging as a fast and reliable technique for characterizing water exchange.

Conclusions:

  • Filter exchange imaging is a promising, noninvasive MRI technique for assessing cell membrane water transport.
  • The method has significant potential as a diagnostic tool for various pathological conditions affecting membrane properties.
  • Further investigation into experimental conditions and limitations will optimize its clinical application.